Ohio Highway Patrol troopers found 42 pounds of cocaine and 2 pounds of black-tar heroin during a traffic stop on the Ohio Turnpike near Perrysburg.
The drugs, troopers said, are worth $2.07 million.
Two California men were arrested after the stop and are being held in the Wood County jail.
Charged with possession and trafficking in cocaine and heroin, and possession of criminal tools, are Bobby Robinson, 24, of Carson, and Christopher Bustamante, 31, of Montebello.
Bond for both suspects is set at $500,000.
Troopers report stopping a tractor-trailer with California registration for a marked-lanes violation at 1:21 p.m. on Monday. A drug-sniffing canine provided troopers probable cause to search the tractor trailer. Authorities found the drugs in the cab of the truck.
If convicted, each man could face up to 41 years in prison and up to an $82,500 fine.