Junior forward Deshaun Thomas scored a team-high 26 points, but received little help on an afternoon that steadily got away from the Buckeyes. Indiana used a 17-10 run to take a 41-33 halftime lead and built its advantage to 16 midway through the second half.
Indiana guard Victor Oladipo led IU with 26 points while forward Cody Zeller added 24.
OSU fell two games behind league-leading Indiana (20-3, 8-2 Big Ten) and Michigan State (20-4, 9-2). The defeat marked the Buckeyes' first back-to-back losses since January, 2010 — a national-best streak dating to January, 2010, when national player of the year Evan Turner was sidelined with a back injury.