The suspect went into the branch at 519 Madison shortly after 4 p.m. and demanded money from an employee. No gun was seen but police said a towel was wrapped around his hand.
He fled on foot with an undetermined amount of money. There were no injuries.
Witnesses described him as a black male, 35 to 40 years old, 5 feet, 8 inches to 5 feet, 10 inches, with freckles on his cheeks.
Anyone with information is asked to call the FBI at 419-243-6122 or Toledo Police Crime Stopper Program at 419-255-1111.