The baby was born to Rachel Kominek, 26, who was killed in the accident on U.S. 20 in Perrysburg Township.
The accident occurred when Mrs. Kominek's husband, Dustin, 24, lost control of his car on the snow-covered highway. The Kominek's car slide sideways and was struck by another vehicle.
Emergency workers delivered the baby inside an ambulance before the tiny victim was flown to the hospital.
A hospital spokesman said the Kominek baby died at 2:19 a.m.
The Lucas County Coroner's office said an autopsy would be conducted this week.