The men, whose names were not released, were taken by the helicopter to a nearby airport to be further assessed by EMS units, according to the Coast Guard station in Detroit.
A water rescue was initiated shortly after 12:30 p.m. Sunday after Lucas County law enforcement officials received a report of an overturned boat.
The Coast Guard was on the scene by about 1 p.m. and rescued the victims shortly before 2 p.m.
At one point, authorities made contact to seek assistance from an air ambulance to try to find the boat.
Spotters along the shore in Jerusalem Township off Anchor Point Road had been trying to find the boat.