Irving scored 11 points in the final 2:33 on four layups and three free throws to give Cleveland back-to-back wins at home for the first time this season and send Boston to its season-high fourth straight loss.
Irving shot 16 for 24 — setting a career high for field goals made — and fell one point short of his career-best scoring total, set at New York on Dec. 15.
Tristan Thompson added 21 points for the Cavaliers.
Rajon Rondo led Boston with 17 points.
CAVS MAKE TRADE: Memphis traded Marreese Speights, Wayne Ellington, Josh Selby, and a future first-round draft pick to Cleveland for Jon Leuer.
The trade is the first big move by the Grizzlies' new ownership and clears about $6 million in salary in getting Memphis under the luxury tax threshold this season.