CLEVELAND -- Alex Rios tripled home the go-ahead run in the 10th inning and the Chicago White Sox beat the Cleveland Indians 5-3 Tuesday night.
Cleveland closer Chris Perez (0-1) yielded a leadoff single to Paul Konerko, who was replaced by pinch runner Brent Lillibridge. After A.J. Pierzynski fouled out, Rios lined a ball over the head of second baseman Jason Kipnis that rolled all the way to the wall in right-center as Lillibridge easily scored.
Rios scored on a fielder's choice, beating the throw home from Kipnis, who fielded a ground ball hit by Alexei Ramirez.
Hector Santiago (1-1) pitched the ninth for his first career win, and Addison Reed worked a perfect 10th for his second save as Chicago won for the second time in eight games.
Rios was in a 3 for 18 skid until getting two singles off starter Justin Masterson -- and his second career triple off Perez. He also hit a walkoff grand slam off Cleveland's closer Sept. 10.
Perez allowed only one run over his previous 13 outings.
Carlos Santana's two-run single off Chris Sale tied it at 3 with a three-run eighth. Until then the Indians had been shut out on four hits by John Danks.
Danks left after yielding singles to Casey Kotchman and Jack Hannahan to open the eighth. Hannahan's ball fell just in front of left fielder Dayan Viciedo, who pulled up near the foul line.
Sale came on and got Johnny Damon to hit a slow roller to shortstop Ramirez, who booted it for an error, loading the bases.
Kipnis grounded out to first, scoring Kotchman and Asdrubal Cabrera walked, reloading the bases. Santana then lined a ball inches from Sale's shoulder and into center field to tie it.
It was Sale's first appearance since being chosen as Chicago's closer by manager Robin Ventura last week. Sale went 3-1 in five starts, including a 7-2 win over Cleveland on May 1.
Indians starter Justin Masterson made 27 pitches in the first inning, allowing five hits and falling behind 2-0.
One run scored on a groundout by Paul Konerko and A.J. Pierzynski added an RBI single.
Cleveland put a runner on third with no outs in the seventh, but Danks quickly got out of it.
Santana doubled on a full-count pitch and took third on a wild pitch before Shelley Duncan walked.
Shin-Soo Choo then popped to center on the first pitch and Michael Brantley lined to Konerko at first base, who quickly tagged Duncan for a double play before the baserunner could get back to the bag.
Masterson, who worked 8 1/3 strong innings to beat Danks in his previous start, struggled to throw strikes, but kept Cleveland in the game.
The right-hander allowed six hits and two runs over six innings, walking five. He twice got out of jams by getting the White Sox to bounce into double plays, both started by third baseman Hannahan.
Pierzynski made it 3-0 in the seventh with an RBI groundout after Chicago loaded the bases against reliever Dan Wheeler on two singles and a walk.
Danks gave up two runs and five hits over seven innings.
NOTES: Ramirez went 0 for 5 and is in a 3 for 24 slump. ... Cleveland LHP Nick Hagadone struck out the side in the ninth, one day after earning his first career save. ... When Hagadone and Tony Sipp saved both ends of a doubleheader Monday, it was the first time since the save became an official statistic in 1969 that two different Cleveland lefties did it in a twinbill. ... In the first game, LHP Jose Quintana worked 5 2-3 scoreless innings, the longest scoreless stretch by a White Sox pitcher in his major-league debut since Jack McDowell's seven scoreless in 1987. ... Indians DH Travis Hafner, hitting .161 this year against lefties, got most of the night off against Danks. Hafner struck out as a pinch hitter for the final out.