Howard pulled from Red Wings' goal in 6-3 setback against Maple Leafs.
Gustav Nyquist scores twice for Detroit, which hands the NHL's newest franchise its first loss.
Glendening's short-handed score with 3:24 to play gives Detroit third win in four games.
Frk scores in regulation for Detroit; Howard records 37 saves.
Zetterberg, Frk score in 3rd period for Detroit in the first regular-season game at Little Caesars Arena.